This is article led me to find the resolution to my issue, but I was able to get everything up and running without actually changing the drivers, essentially only a complete shutdown of the server and the tape drive.
1. Power down the backup exec server
2. Power down the tape drive
3. Power up the tape drive, wait for a complete boot
4. Power up the backup exec server
That worked for me to get the drive useable again. If this doesn’t work for you, see the link for information regarding use of a different driver for your media changer.